山茱萸水提物抗氧化及降尿酸能力研究

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Study on Antioxidant and Uric Acid-Lowering Effects of Cornus officinalis Aqueous Extract

DING Bonan， XIA Hongjuan， QIN Si* （HunanAgriculturalUniversity，Changsha41Ol28，China）

Abstract： Objective： To investigate the antioxidant and uric acid-lowering effects of Cornus offcinalis aqueous extract （CAE）. Method： In vitro experiments were performed to evaluate the scavenging capacity of CAE against ABTS+ and DPPH free radicals，as wellas its inhibitory effect on xanthine oxidase （XOD）activity. Additionaly a hyperuricemia HepG2 cell model was established to assesstheuric acid-lowering eficacyofCAE.Result： The halfmaximal inhibitory concentrations of CAE for ABTS+， DPPH， and XOD were 0.19， 0.50， 0.43mg?mL-1 ，respectively. In the HepG2 cell model， CAE significantly inhibited XOD activity （ p<0.01 ）.Conclusion： As a substance with both antioxidant and uric acid-lowering activities，CAE shows potential application value in the development of functional foods.

Keywords： Cornus officinalis aqueous extract; hyperuricemia; antioxidant; uric acid-lowering

高尿酸血癥（Hyperuricemia，HUA）是一種嘌呤代謝紊亂導致的代謝性疾病，其全球患病率呈逐年上升趨勢[]。（剩余4403字）