運(yùn)動(dòng)干預(yù)鐵死亡進(jìn)程改善非酒精性脂肪肝的機(jī)制研究

【中圖分類號(hào)】G804 【文獻(xiàn)標(biāo)識(shí)碼】A 【文章編號(hào)】2095-2813（2025）21-0005-04

Research on Mechanism of Exercise Intervention in Iron Death - Process to Improve Non-AlcoholicFatty Liver Disease

ZHANG Xinyu

InnerMongoliaNormal UniversityInstituteofPhysicalEducation，Hohhot，InnerongoliaAutonomousRegion， China

[Abstract]Physical exercise is regarded asan efectivenon-pharmaceutical means tocombat metabolicdiseases.Inrecent years，aerobic exercisehas shown remarkable results in the treatment of non-alcoholic fatt liver disease，which can significantly reverse thedegenerationoflivercelsinfatyliverand alleviate thecondition.Iron dependent programmed cell death isanovelformofcelldeath thatis dependentoniron.Researcheshaveshown thatintheliverof patients withnon-alcoholicfattyliverdiseasetheexpressionofGPX4proteinisdecreasedandirondeathisexacerbated.Exercise can inhibit iron death and improve non-alcoholic faty liver disease by down-regulating lipid peroxidation，upregulating the System Xc-. -GSH-GPX4 pathway and regulating iron metabolism.

[Keywords] Exercise; Iron death;NAFLD;GPX4

肝臟是鐵穩(wěn)態(tài)的關(guān)鍵場(chǎng)所，也是機(jī)體主要的代謝器官。（剩余7964字）