曲唑酮聯(lián)合氟伏沙明對抑郁癥患者睡眠 及血單胺類神經(jīng)遞質(zhì)的影響

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Impacts of Trazodone Combined with Fluvoxamine on Sleep Quality and Blood Monoamine Neurotransmitters Levels in Patients with Depression

YANG Li

（Department of Psychiatry，The Third People's Hospital of Changshu City，Changshu 2155oo，China）

AbstractObjective：Toexplore the impacts of trazodonecombined with fluvoxamineonsleepqualityand blood monoamine neurotransmiterslevelsinpatientswithdepresion.Methods：Seventypatientswithdepressioninthehospitalwereselectedfrom March 2O22 to March 2O24，and were randomly divided into an observation group（ n=35 ，treated with trazodone and fluvoxamine） and a control group（ n=35 ，treated with fluvoxamine）.After 2 months of treatment，the sleep structure，serum indicators，psychological symptomsscores，slepqualityscores，andadverse events werecomparedbetweenthetwo groups.Results：Aftertreatment， both groupsshowed increasesinsleepuration，apideyemovementsleeproportionsleepeficiency，on-REMstagepopr tionandlevelsofoyaeodoleacticcidndeie.rtortsedtose intheobservationgroupthanintecontrolgroup.Aditionall，sleeplatencyon-REMsages1and2proportions，ufwakenings，HamiltonDepresionRatingScale-17scoresandsleepqualityscoreswerealloweraftertreatment，withtheoservation group showing lower values than the control group（ P<0.05 ）. There was no statistical significance in the total incidence rate of adverse events between groups（ P>0.05 ）. Conclusion： Trazodone combined with fluvoxamine can improve the sleep structure of patients withdepresion，ndmayfurtherenancetheantidepressantefetsbyregulatingthelevelsofbloodmonoaminenuro transmitters. This therapy has good safety.

KeywordsDepresion；Insomnia；Trazodone；Fluvoxamine；Sleepstructure；Blod monoamineneurotransmiters；Sleepquali ty：Depression

中圖分類號：R749.4;R338.63 文獻(xiàn)標(biāo)識碼：A doi：10.3969/j.issn.2095-7130.2025.02.051

抑郁癥是一種高患病率和復(fù)發(fā)率的精神障礙，其核心癥狀包括情緒低落、興趣缺乏，且常伴發(fā)失眠癥狀，失眠與抑郁癥間存在雙向聯(lián)系，抑郁癥患者常難以人睡，夜間頻繁覺醒甚至早醒，這種失眠狀態(tài)加劇抑郁情緒，導(dǎo)致病情惡化，形成惡性循環(huán)[1]。（剩余4329字）