不同低氧耐力飛行人員訓(xùn)練前后尿中皮質(zhì)醇和睪酮及其代謝產(chǎn)物比較

打開文本圖片集

[中圖分類號(hào)]R852 [文獻(xiàn)標(biāo)志碼］A [文章編號(hào)] 2096-5532（2025）03-0391-04 doi：10.11712/jms.2096-5532.2025.61.094 [開放科學(xué)（資源服務(wù)）標(biāo)識(shí)碼（OSID）]i [網(wǎng)絡(luò)出版] https：//link.cnki.net/urlid/37.1517.R.20250731.1609.004; 2025-08-0113：29：05

Comparisonofurinarycortisolandtestosteroneandteirmetabolitesamongaviationpersonnelwithdifferenthypoxicendurancelevels before and after training ZHENG Hongxia ， PAN Xiangrong， WANG Peng， TIAN Jianquan， WANG Zheng，LIN Shuang （Qingdao Special Servicemen Recuperation Center of PLA Navy，Qingdao 266O71，China）

[Abstract]ObjectiveTocomparetheurinarycontentofcortisol，testosterone，andtheir metabolitesamongflight person nelwithdiferenthypoxiatolerancelevelsbeforeandaftertraining，andtofindconvenientdetectionindicatorsforimmediatehy poxiatoleranceaessmentforflightpersonel.MethodsMaleflightpersonnelwhounderwenthypoxiatolerance trainingatour center were selected.Using the KK-1type anti-Gandanti-hypoxia detection device developed byamedicalresearchinstitute，30 participants eachwereselectedintothreegroupsaccordingtothehypoxiatoleranceresults：qualifiedgroup，goodgroup，and excellentgroup.Bygaschromatography-masspectrometry，thethree groupswere measuredforthelevelsofcortisol，testosteroneand their metabolites，including epitestosterone（ET），etiocholanolone（Etio），androsterone（ An） ， 5α -androstane 3α 17β? diol（5α）， 5β? androstane 3α，17β -diol （5β） ，11-hydroxytestosterone（11-OHT），11-hydroxyandrostenedione（11-OHA4），17-hydroxycorticosteroids（17-OH），and17-ketosteroids（17-O）beforeandaftertraining.ResultsAcrossthethre groups，thelevelsof theindicators were all significantly increased after training Φt=-17.479 to -3.726 ， P<0.05 ）.The covariance analysis showed that individual hypoxia tolerance significantly affected cortisol，testosterone，and their metabolites （ F=3.173 to 9.638， P<0.05 ）；compared withthegoodandqualified groups，theexcelentgroupshowed significantly greaterchanges incortisol，testosterone，and their metabolites after training ?P<0.05 ）；and among all the indicators，the changes in An，Etio，and ET in the excellent group were more prominentConclusionThesecretionofsteroid hormones isafectedbyindividualhypoxiatoleranceabilityUrinary An，Etio，andEareotetialoveietandimeatessessmntiicatorforteoiatoleanceofflghtprsoelatig altitudes.

[Key words]hypoxia；androgens；aviation；pilots

急性高空低氧嚴(yán)重威脅飛行安全]，低氧有效意識(shí)時(shí)間可反映個(gè)體耐低氧能力，是急性高空低氧耐力模擬訓(xùn)練中常用的檢測(cè)指標(biāo)，但由于場(chǎng)地、設(shè)備等限制，無法在執(zhí)行飛行任務(wù)前對(duì)飛行人員低氧耐力進(jìn)行即時(shí)評(píng)估，因此亟需開發(fā)便捷、敏感的即時(shí)低氧耐受能力評(píng)估指標(biāo)。（剩余5720字）