阿膠和阿膠肽對(duì)血管內(nèi)皮細(xì)胞氧化損傷的作用研究

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關(guān)鍵詞阿膠；阿膠肽；過(guò)氧化氫；人臍靜脈內(nèi)皮細(xì)胞；氧化損傷

中圖分類號(hào)R285文獻(xiàn)標(biāo)識(shí)碼A

文章編號(hào) 0517-6611（2025）08-0162-06

doi：10.3969/j.issn.0517-6611.2025.08.035

開(kāi)放科學(xué)（資源服務(wù)）標(biāo)識(shí)碼（OSID）：

Abstractbective]Toaalyeteoleoforiollini（Ejia）adEjpeptideinoxidatiestressijuyofscularedothelialcels andthemechanismoftheirrole.[Metod]Themodelofhumanumbilicalveinendothelialcellinjuryinducedbyhydrogenperoxide（ ） wasestablishedTetsofEjaodEjapeptideontesurvialateofumanmblcalvendothelialcs（HUVEC）beforeadfter modelingweredteedbyCCK-8eeectsofEjandEjaopeptideonthactitiesofcellsuperoxidedsmutase（SOD）glutatioepe oxidase（GSH-px），lactatedehydrogenase（LDH）andtecontentsofalondialdehde（MDA）ascuarendthelialgrowthfctor（EGF）， interleuki-6（-6）ricide（NO）reded.esultEdEpeptidouldectivelyproteeproliferatiodo of HUVEC，and could effectively resist the proliferation inhibition caused by oxidative injury. Ejiao and Ejiao peptide could significantly inhibit the excessive production of MDA and LDH， Ejiao could significantly increase the enzyme activity of GSH-px，Ejiao peptidecouldsignificantlyincreasetheexpressonlvelofSODandrepirteoidativeijuyofHUVCBothEjiaoadEjapeptideould effectivelyproefyulardolpottsdelalfucioteeoVGy vascularendoelialelluceotf6ooteogsisduceatoactoocisf EjiaoandEjioeptideducinoidativestressofECabelatedtprovingcellgrowhndproliferatiohncingeltioidantenzymeactivityrotigtexpresiofsredoelialgowthfctorandprootigtesetioofbasadelal cells.

Key wordsCorii colla asini（Ejiao） ；Ejiao peptide；Hydrogen peroxide ）； Human umbilical vein endothelial cells（HUVEC） ；Oxida-tive injury

由于當(dāng)今世界的人口日益老齡，許多慢性疾病如冠狀動(dòng)脈粥樣硬化、糖尿病和脂肪肝的患病比例正在不斷上升[1]與高血壓、高血脂、衰老等疾病密切相關(guān)的血管內(nèi)皮細(xì)胞功能的損傷研究逐漸引起人們的重視[2]。（剩余10719字）