κB</sub> )信號(hào)通路探討明君散對(duì)動(dòng)脈粥樣硬化(AS)大鼠的影響。方法：采用高脂飼料聯(lián)合維生素 <img src="/qkimages/zxxn/zxxn202514/zxxn20251408-1-l.jpg" with="17px" style="vertical-align: middle;"> 法建立大鼠AS模型，分為空白組、模型組、西藥組[阿托伐他汀 1mg/(kg?d) ]、明君散低劑量組 2.35mg/(κg?d) ]、明君散中劑量組 4.70mg/(kg?d) ]、明君散高劑量組 [9.40mg/(kg?d)] ，每組10只。灌胃給藥8周后，檢測(cè)血清總膽固醇（TC）、三酰甘油（TG）、高密度脂蛋白膽固醇（HDL-C）、低密度脂蛋白膽固醇（LDL-C)水平；采用蘇木精-伊紅（HE)染色觀察大鼠胸主動(dòng)脈組織形態(tài)學(xué)變化；實(shí)時(shí)熒光定量聚合酶鏈?zhǔn)椒磻?yīng)（RT-PCR)檢測(cè)大鼠主動(dòng)脈TLR4、MyD88、NF- ?κB mRNA表達(dá)水平；蛋白免疫印跡法(Western Blot)檢測(cè)大鼠主動(dòng)脈TLR4、MyD88、NF- Π<sub>κB</sub> 蛋白表達(dá)水平。結(jié)果：與模型組比較，西藥組和明君散中劑量組、明君散高劑量組血清TC、TG,LDL-C水平降低，HDL-C水平升高( P<0.05 或 P<0.01 )；西藥組和明君散各劑量組大鼠主動(dòng)脈組織中TLR4、MyD88、NF- κB mRNA和蛋白表達(dá)水平均降低（ P<0.05 或 P<0.01 ）。結(jié)論：明君散可能通過抑制TLR4/MyD88/NF- ?κB 信號(hào)通路發(fā)揮抗動(dòng)脈粥樣硬化作用。-龍?jiān)雌诳W(wǎng)" />

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明君散對(duì)動(dòng)脈粥樣硬化大鼠TLR4/MyD88/NF-κB信號(hào)通路的影響

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doi：10.12102/j.issn.1672-1349.2025.14.008

TheEffectofMingjun Powderonthe TLR4/MyD88/NF- κB Signaling Pathway in Atherosclerotic Rats CHESihua1，YANG Na2 ZHENGWenyu2，ZHANGShumao？，SHI Guijun2

1.ChangchunUversityfineedicinanghn30oinina;angnspitalofaditioalCie Changchun3ooo，Jilin，China;3.JlinProvincialDisabledPersons FederationRehabilitationHospital

CorrespondingAuthor SHlGuijun，E-mail：zsmsgj @ 163.com

AbstractObjective：ToxploretheefectofMingjunPowderonatheroscleroticratsbasedonteTollikereceptor4（R4）eloid differentiation protein 88（MyD88）/nuclear factor- κB（NF-κB） signaling pathway.Methods：The atherosclerotic model of rats was established byhigh-fat feed combinedwith vitamin method.The rats were divided into the blank group，the model group，the Western medicine group[atorvastatin 1mg/（kg?d）] ，the low-dose Mingjun Powder group[2.35 mg/（kg?d）] ，the medium-dose Mingjun Powder group[4. 70mg/（kg?d）] and the high-dose Mingjun Powder group [9.40mg/（kg?d）] ，with 10 rats in each group.After gavaging for eight weeks，the levels of serum totalcolestes）otit detected.Hematoxylineosin（HE）stainingwasusedtoobservethehistologicalmorphologicalchangsofthethoracicaortainratsTe expressions of TLR4，MyD88 and NF- κB mRNA in the aorta of rats were detected by reverse transcription polymerase chain reaction （RT-PCR）.The expressionsof TLR4，MyD88，and NF-κB proteinsintheaorta of ratsweredetected byWestern Blot.Results：Compared withthe modelgroup，thelevelsofserumTC，TGandLDL-Cin theWestemmedicinegroup，themedium-dseMingjunPowdergroup， and the high-dose Mingjun Powder group decreased，and the level of HDL-C increased P<0.05 or P<0.01 ）.The expressions of TLR4， MyD88， NF- κB mRNA and protein in the aortic tisues ofrats in the Westem medicine groupand each dose Mingjun Powder groupsall decreased（ P<0.05 or P<0.01 ）.Conclusion：Mingjun Powder might playananti-atherosclerotic efect by inhibiting the TLR4/MyD88/NF-kB signaling pathway.

Keywordsatherosclerosis；MingjunPowder;Tollikereceptor4/myeloid diferentiationprotein88/nuclearfactor- κB signaling pathway; blood lipid; rats; experimental study

《中國(guó)心血管健康與疾病報(bào)告2021》顯示，我國(guó)的心血管病患病率總體呈逐年攀升態(tài)勢(shì)，心血管疾病罹患人數(shù)約3.3億例，其中冠心病患病人數(shù)可達(dá)1139萬例1。（剩余9200字）

目錄
monitor