姜黃素抗抑郁作用機(jī)制的研究進(jìn)展

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中圖分類(lèi)號(hào)R285；R965 文獻(xiàn)標(biāo)志碼A 文章編號(hào)1001-0408（2025）09-1147-06

DOI 10.6039/j.issn.1001-0408.2025.09.22

ABSTRACTCurcumin is anatural yellwpigment，anatural phenolic antioxidant extractedfromtherhizomesof Curcuma longa andCurcumaeRhizomaofthegingerfamily，withanti-inflammatory，anti-tumorandantioxidant properties.Inrcentyears，ithas beenfoundthatcurcuminalsohasgoodantidepressantproperties，nditisconsideredasafeandefectiveantidepressntpotential drug.Themechanismofcurcumin'santidepressanteficacymainlyincludesregulatingneurotransmiters，modulatingthe hypothalamic-pitaryadrealaxis，egulatingbaidriedeurotropicctoribiinguroflammationibiigidatie stress，andregulatinggutmicrobiota，etc.andthereisanoverlappngandsynergistictherapeuticefectoftheabove mehanisms. Atpresent，theantidepressantmechanismofcurcuminisstillnotfullyunderstod，andwillbecombinedwithmulti-omics technology，new formulation technology，and clinical trials to obtain further breakthroughs in the future.

KEYWORDS curcumin；depression；neurotransmitter；inflammatory response；oxidative stress；mechanism

抑郁癥是一種臨床常見(jiàn)的慢性、復(fù)發(fā)性精神疾病，嚴(yán)重影響患者的生活質(zhì)量，甚至增加了死亡風(fēng)險(xiǎn)。（剩余14139字）