基于網(wǎng)絡(luò)藥理學(xué)與分子對(duì)接探討舒泌通膠囊“異病同治”治療良性前列腺增生和慢性前列腺炎的作用機(jī)制*

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Exploration of Action Mechanism of Shubitong Capsule in the Strategy of the Same Treatment for Different Diseases in the Treatment of Benign Prostatic Hyperplasia and Chronic Prostatitis Based on Network Pharmacology and Molecular Docking

JIAO Xu-ran1 ，LI Yan-feng1，2 ， ZHANG Chun - he2

（1.YunanUesitfdolseedinOstclcalCfif Traditionleistfledalclsalfdlec 【Abstract】Objective：To explore the mechanism of action of Shubitong Capsule in the treatment ofbenign prostatic hyperplasia（BPH）and chronic prostatitis（CP）by using network pharmacology methods. Methods： The components and action targets of Shubitong Capsule were obtained through the TCMSP database.The action targets of CP and BPH were obtained through the GeneCards，OMIM，PharmGkb and DrugBank databases.The Venn diagram of the common effective targets of Shubitong Capsule in the treatment of CP and BPH was drawn through the Lianchuan Biological Cloud platform.The protein- protein interaction （PPI） network of common genes was constructed through the STRING database.The core targets were screened out through the Cytoscape software，and anetwork diagram containing multiple elements such as“traditional Chinese medicine-active ingredients-potential targets-diseases”was successfullyconstructed.Firstly，GO and KEGG enrichment analyses were conducted using R software，and thenthe molecular docking was verified using Autodock4.2.6 software to verifythecore targets and components.Results：After screning，Shubitong Capsule contains 58 potential active ingredients of traditional Chinese medicine，211 targetsand 3，542 disease targets.After taking the intersection，171 potential therapeutic targets were obtained.Thecore components included luteolin，quercetin and kaempferol，and the core targets were PTGS2，HSP90AA1，PTGS1，etc.GO analysis showed that the therapeutic targets were related to processes such as the response to exogenous stimuli，the process of neuronal apoptosis and glandular development，mainly involving signaling pathways such as lipid and atherosclerosis and PI3K -Akt. Conclusion：Shubitong Capsule may exert therapeutic effects on BPH and CP by regulating targets such as AKT1，TNF，and IL-6，as well asbyregulating responses to exogenous stimuli，bacterial-derived molecules and lipopolysaccharides.

【Key words】Benign Prostatic Hyperplasia;； Chronic Prostatitis； Shubitong Capsule； Same Treatment for DifferentDiseases ； Network Pharmacology；Molecular Docking

良性前列腺增生（benignprostatichyperplasia，BPH）和慢性前列腺炎（chronicprostatitis，CP）同為泌尿男科的常見病，在臨床癥狀方面有許多的相似之處，均可表現(xiàn)為下尿路癥狀，如尿頻、尿急、尿不盡等。（剩余11066字）