基于“陽微陰弦"理論探討血管平滑肌細胞增殖與遷移在動脈粥樣硬化中的作用

本文引用：.基于“陽微陰弦"理論探討血管平滑肌細胞增殖與遷移在動脈粥樣硬化中的作用[J].湖南中醫(yī)藥大學學報，2025，45（5）：933-938.

[關鍵詞]動脈粥樣硬化；血管平滑肌細胞；細胞增殖；細胞遷移；表型轉化；陽微陰弦；胸痹心痛 [中圖分類號]R256.2 [文獻標志碼]A [文章編號]doi：10.3969/j.issn.1674-070X.2025.05.022

[Abstract]Atherosclerosis （AS）isacomplexvasculardisease characterizedbylipiddepositionandtheaccumulatioof inflammatorycellwithinthearterialwall，oftenleadingtoadversecardiovascularandcerebrovascularevents.Inrecentyears， vascularsmoth musclecell（VSMC）phenotypicswitching，particularlytetransitionfromtheontractiletothesyntheticphenotype， hasbeenrecognizedasakeymechanism inASprogresionContractile VSMCsprimarilymaintainvasculartoneandstructural stability，werassthticVshitanedsreoryproiferative，ndgatoyapacitis，trebypromotingpatolical vascularremodeling.InTCMtheorythefunctionalcharacteristicsofcontractileVSMCscanbeanalogizedto"yang"，whilethe biosyntheticactivityofsytheticVMCscorespondsto"yin"，Tedynamictransformationbetweethephenotypescoresods，to acertainextent，withtheTCMpathogenetictheoryof"yangdeficiencyandyinexcess".Basedonthis，thestudyintegratesthe

TCMtheorywithmoderncelularandmolecularmechanismstoinvestigatetheroleofVSMCphenotypicswitchingintheAS pathogenesis.Aditionaly，itsystematicallyeviewsTCMherapeuticprinciplesandmethods，ndthemechanismsandmolecular targetsofvarioussingleherbalcompoundsandformulasinregulating VSMCphenotypicswitchingandinhibitingabnormal proiferationandmigration.Thisstudyaimstoprovidenewinsightsforboththeclinicalmanagementandfundamentalresearchof AS while offering a unique perspective on the role of VSMCs in AS from the standpoint of TCM.

[Keywords]atheroslerosis;vascularsmothmusclecels;cellproliferation；cell migration;phenotypicswitching;yang deficiency and yin excess; chest bi-impediment and cardiac pain

動脈粥樣硬化（atherosclerosis，AS）是一種常見的血管疾病，其特征是動脈內膜下脂質沉積，伴隨炎癥細胞浸潤和纖維帽形成，最終導致動脈壁增厚和硬化。（剩余12307字）