二陳湯合六君子湯化裁聯(lián)合常規(guī)西醫(yī)治療慢性阻塞性肺疾病急性加重期療效觀察

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本文引用：，．二陳湯合六君子湯化裁聯(lián)合常規(guī)西醫(yī)治療慢性阻塞性肺疾病急性加重期療效觀察[].·湖南中醫(yī)藥大學(xué)學(xué)報(bào)，2025，45（5）：904-909.

[關(guān)鍵詞]二陳湯；六君子湯；慢性阻塞性肺疾病急性加重期；痰濁阻肺證；療效；趨化因子 [中圖分類號(hào)]R256.1 [文獻(xiàn)標(biāo)志碼]B [文章編號(hào)]doi：10.3969/j.issn.1674-070X.2025.05.017

[Abstract]Objective Toexplore theeficacyof modifiedErchenDecoctionandLiujunziDecoctioncombined with conventional western medicine therapyintreatingacuteexacerbationof chronicobstructive pulmonarydisease （AECOPD）（phlegm dampnessaccmulating inthe lungpatern）. Methods Atotalof136AECOPDpatients with phlegmdampnessaccumulatinginthe lungpaternadmitedtotheEighthPeoplesHospitalofHefeifromJanuary2022toJanuary2O24wereselectedandrandomly dividedintoobservationgroupandcontrolgroup.Thecontrolgroupreceivedconventionalwesternmedicinetherapy，whilethe observationgroupreceivedoraladministrationofmodifiedErchenDecoctionandLiujunziDecoctioninadition tothetreatment provided tothecontrolgoup ClicaleficacyTCMpatensoresbloodasparameters，lungfunctioindicatorsCOPAe Test （CAT scores，6-minutewalkingdistance （6MWD），serumlevelsof CX chemokineligand1（CXCL10）andCX3chemokineligand 1（CX3CL1） beforeandaftertreatment werecomparedbetweenthetwo groups，andthesafetyof medication wasanalyzeda well Results The total effctive rate of the observation group was higher than that of the control group （ P- <0.01）.Compared with before treatment，TCMpattrnscores，CATscoresarterialpartialpresureofcarbondioxide（aCO），andserum levelsof CXCLnd CX3CL1 decreased in both groups after treatment （ P- forced expiratory volume in one second to forced vital capacity （FEV/FVC） ratio， FEV1 to the predicted value （FEVi%pred），and 6MWDaftertreatment（POO1），andtheaboveindicatorsintheobservation groupwerehigherthanthoseinthecontrol group（001）. Duringtreatment，noobviousadverseeventsocured ineither group.ConclusionForAECOPDpatientswith phlegmdampness accumulatinginthelungpatern，thetreatment withmodifiedErchenDecoctionandLiujunzi Decoctioncanrelieveclinical symptoms，improvepulmonaryventilation function，enhancethequalityof life，andreduce theserum levelsofCXCL10and CX3CL1， exhibiting significant efficacy and high safety.

[Keywords]Erchen Decoction;Liujunzi Decoction；acuteexacerbation of chronic obstructive pulmonarydisease；phlegm dampness accumulating in the lung pattern; therapeutic effct; chemokine

慢性阻塞性肺疾?。╟hronicobstructivepulmonarydisease，COPD）是常見呼吸系統(tǒng)疾病，研究數(shù)據(jù)顯示，我國(guó)COPD患病人數(shù)接近1億。（剩余8568字）