基于數(shù)據(jù)挖掘、網(wǎng)絡(luò)藥理和分子對(duì)接研究高血壓合并糖尿病(陰虛型）的用藥規(guī)律及作用機(jī)制

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MedicationRegularityMechanismHypertensionComplcatedwit Dabetes Melitus（YinDeficencyType）BasedonDataMining， Network Pharmacology， Molecular Docking SONGJiayuan1，LIShuling2，MA Chun2，WANG Yu2，YANGLihua2

1.Westem

，Hosangn

3. Medicine

Corresponding AuthorYANG Lihua，E-mail： ylh7239@126.com

AbstractObjective：Toexplorethemedicationrulesactionmechanismstraditionalmedicineprescriptionsforpatints withhypertensiondiabetesmeliuswitndeficiencytypeMethods：Aprescriptiondatabasewasonsructedfortatisticalanalysis thefrequencycategoryatureflavor，tomeridiantropismtraditionalmedicinedeepminingsuchasuster analysis，ssiationaalysisndomplexetworkaalysis，tommaetoredrugpisrtheitersectiotargtfdrugpair disease，protein-proteininteractions（PPl）networkwasconstructedcoretargetwasscreenedforgenentology（OKyto EncyclopediaGenesndGenomes（KG）ecmentanalysis.e"tradionalCineeedicinomponenttargepathaetork wasconstructedtoreencorecmponntstecorecomponentsndoretargetseredckedespectivelyesutsAtotal54 arileswereiudedvoing63rousradioalCinsemeicieprescritios，ontainng4indsiesebih cumulativefrequency786.ThetopthreefrequentlyuseddrugswereRehmanniaglutinosa，Lyciumbarbarum，Uncaria rhynchophyll.Teproportiontonifyingdrugsastheghestonamongthem.heirmainfavorsweresweetcoldteymainly affecthelivermeridianAssociationruleanalysisidentfied1coredrugpaircombinationsclusteranalysisyielded4combinatios.e coredrugpaifcaoaiotidiserteditscttouhympotsheetimferold targetingP53，interlekin-6（L6roteininaseAKT）epideralgrowthactoreceptorEGFR）ndpartcipatedinpthwa includingTumorecosisfactor）nterkin-177）dacedglyatiodproductsAGE）eceptorfordvancdatio products（RAGE），mitogen-activatedproteinkinase（MAPK）.MoleculardckingshowedthatHSP90AB1-yohimbinewasthecoplex withthehighestbindingafityocluson：NourishingYinsuppessngYangisthemaintreatmentmethdforYindeficencytype hypertensionomplicatedwitdiabetesmeliusUncar-ConchaHaliotiscanexertistherapeuticefecttroughmutiplecoonts， targets， pathways，this study willprovidea reference scheme forclinical treatment.

Keywordshypertension; diabetes melitus;data mining; network pharmacology; molecular docking

糖尿病是一種在遺傳及環(huán)境因素共同作用下發(fā)生的以血糖升高為典型臨床特征的內(nèi)分泌代謝性疾病1。（剩余8905字）