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基于加權(quán)基因共表達(dá)網(wǎng)絡(luò)分析篩選動(dòng)脈粥樣硬化鐵死亡相關(guān)Hub基因

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Screning HubGenesAssociatedwithFerropsisinAtherosclerosis UsingWeightedGeneCoexpressonNetworkAnalysis WANG Miaoqian1,MA Mingfeng2

1. Colege ,;2. Province/

Afiliated , O322oo

Corresponding AuthorMA Mingfeng,E-mail: mamingfeng106@ sina.com

AbstractObeteTdentifyonfopateddiretiallexpessdnesiseosisAusingti analysis.Methods:BiinformaticaalysiswasconuctedinGSE12288GSE9710andGE28829.The"limmapackagewasused identifydiferentialyexpressedgnes(DEGs)Difrentkindsenrichmentanalyseswereperformedtindoutterelevantpathays. WeightedcorelationnetworkanalysisWGCNA)wasperfoedconstructcoexpressionnetworkexplremarkercorelationsand identifymportantinteractinggenemodulescorelatedwitSCscapewasusedvisuaieferropsisrelaedgenesandomenon codingRNAsinteractionnetwork.CIBROSORTwasusedevaluateabundance immunocytes,revealingtheefect immune responseinAus:itrosisedifrellpredsDseauchriigt), glutamatereceprsubunit 3(GRIA3),Promin-2(PROM2),interleukin-1β(IL1β)andsoon.Geneonlog(GO)analysisandGeneSet EnrichmentAnalysis(GSEA)foundpathwayssuchasgulatiohelialcellprliferationmembraneraftndvasuladothelia growthfacr(VEGF)pathwayenrichedinthisdiseases.Regularynetworkandimmunocyteinfitrationabundanceanalysiswere performedevaluatetheunderlyingmechanisminAS.Conclusion:ThityDEGsassociatedwithferopsiswerefoundinASand corelatedwitpathologicalprogresiontedisease.Tepathogenesisandpotentialmoleculartargetsthediseasewerediscused forpotentialtreatmenttargetsinthefuture.Howeverteunderlyingpathogenesisandpotentialmoleculartargetsstiledore comprehensive and in-depth studies.

sywordsatherosclerosis; ferropsis; Hub gene; gene co-expression; bioinformatics analy

動(dòng)脈粥樣硬化(atherosclerosis,AS)是一種主要影響大中型動(dòng)脈的慢性炎癥性疾病[13],是由氧化型低密度脂蛋白(oxidized lowdensity lipoprotein,ox-LDL)膽固醇在動(dòng)脈壁中積聚,從而引發(fā)一系列連鎖炎癥反應(yīng)。(剩余18310字)

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