基于加權(quán)基因共表達(dá)網(wǎng)絡(luò)分析篩選動(dòng)脈粥樣硬化鐵死亡相關(guān)Hub基因
Screning HubGenesAssociatedwithFerropsisinAtherosclerosis UsingWeightedGeneCoexpressonNetworkAnalysis WANG Miaoqian1,MA Mingfeng2
1. Colege ,;2. Province/
Afiliated , O322oo
Corresponding AuthorMA Mingfeng,E-mail: mamingfeng106@ sina.com
AbstractObeteTdentifyonfopateddiretiallexpessdnesiseosisAusingti analysis.Methods:BiinformaticaalysiswasconuctedinGSE12288GSE9710andGE28829.The"limmapackagewasused identifydiferentialyexpressedgnes(DEGs)Difrentkindsenrichmentanalyseswereperformedtindoutterelevantpathays. WeightedcorelationnetworkanalysisWGCNA)wasperfoedconstructcoexpressionnetworkexplremarkercorelationsand identifymportantinteractinggenemodulescorelatedwitSCscapewasusedvisuaieferropsisrelaedgenesandomenon codingRNAsinteractionnetwork.CIBROSORTwasusedevaluateabundance immunocytes,revealingtheefect immune responseinAus:itrosisedifrellpredsDseauchriigt), glutamatereceprsubunit 3(GRIA3),Promin-2(PROM2),interleukin-1β(IL1β)andsoon.Geneonlog(GO)analysisandGeneSet EnrichmentAnalysis(GSEA)foundpathwayssuchasgulatiohelialcellprliferationmembraneraftndvasuladothelia growthfacr(VEGF)pathwayenrichedinthisdiseases.Regularynetworkandimmunocyteinfitrationabundanceanalysiswere performedevaluatetheunderlyingmechanisminAS.Conclusion:ThityDEGsassociatedwithferopsiswerefoundinASand corelatedwitpathologicalprogresiontedisease.Tepathogenesisandpotentialmoleculartargetsthediseasewerediscused forpotentialtreatmenttargetsinthefuture.Howeverteunderlyingpathogenesisandpotentialmoleculartargetsstiledore comprehensive and in-depth studies.
sywordsatherosclerosis; ferropsis; Hub gene; gene co-expression; bioinformatics analy
動(dòng)脈粥樣硬化(atherosclerosis,AS)是一種主要影響大中型動(dòng)脈的慢性炎癥性疾病[13],是由氧化型低密度脂蛋白(oxidized lowdensity lipoprotein,ox-LDL)膽固醇在動(dòng)脈壁中積聚,從而引發(fā)一系列連鎖炎癥反應(yīng)。(剩余18310字)
-
-
- 中西醫(yī)結(jié)合心腦血管病雜志
- 2025年16期
- 含冰片與不含冰片中成藥治療急性...
- 基于加權(quán)基因共表達(dá)網(wǎng)絡(luò)分析篩選...
- 基于數(shù)據(jù)挖掘、網(wǎng)絡(luò)藥理和分子對(duì)...
- 利用掌型中醫(yī)經(jīng)絡(luò)檢測(cè)儀觀察社區(qū)...
- 基于DNA甲基化差異性探討太陰...
- 前庭性偏頭痛病人腦電特征與中醫(yī)...
- LncRNAH19靶向miR-...
- 穿心蓮內(nèi)酯調(diào)節(jié)AMPK/NLR...
- SIRT1激動(dòng)劑通過(guò)調(diào)控線粒體...
- 膿毒癥心肌功能障礙的研究現(xiàn)狀和...
- 心室-動(dòng)脈偶聯(lián)在射血分?jǐn)?shù)保留的...
- 經(jīng)導(dǎo)管三尖瓣介入治療在三尖瓣反...
- 補(bǔ)脾通絡(luò)方輔助治療冠心病微血管...
- 75歲以上冠狀動(dòng)脈粥樣硬化性心...
- 保元湯合桃紅飲方聯(lián)合琥珀酸美托...
- 基于AR技術(shù)的心臟有氧康復(fù)訓(xùn)練...
- 心力衰竭病人OSAHS患病情況...
- 自擬強(qiáng)心利水方聯(lián)合重組人腦利鈉...
- 無(wú)ST段抬高的院外心臟驟停病人...
- 冠狀動(dòng)脈粥樣硬化病人左前降支中...
- 自擬黃精健腦方治療腎虛痰瘀型腦...
- 老年綜合征與抑郁的相關(guān)性研究...
- 基于陰陽(yáng)理論探討線粒體質(zhì)量控制...
- 郭維琴教授采用益氣活血法論治老...
- 吳偉教授運(yùn)用熱毒血瘀理論治療重...
- 陳士鐸辨治心痛特色淺析...
- 青年冠狀動(dòng)脈栓塞1例...