基于加權(quán)基因共表達(dá)網(wǎng)絡(luò)分析篩選動(dòng)脈粥樣硬化鐵死亡相關(guān)Hub基因

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Screning HubGenesAssociatedwithFerropsisinAtherosclerosis UsingWeightedGeneCoexpressonNetworkAnalysis WANG Miaoqian1，MA Mingfeng2

1. Colege ，；2. Province/

Afiliated ， O322oo

Corresponding AuthorMA Mingfeng，E-mail： mamingfeng106@ sina.com

AbstractObeteTdentifyonfopateddiretiallexpessdnesiseosisAusingti analysis.Methods：BiinformaticaalysiswasconuctedinGSE12288GSE9710andGE28829.The"limmapackagewasused identifydiferentialyexpressedgnes（DEGs）Difrentkindsenrichmentanalyseswereperformedtindoutterelevantpathays. WeightedcorelationnetworkanalysisWGCNA）wasperfoedconstructcoexpressionnetworkexplremarkercorelationsand identifymportantinteractinggenemodulescorelatedwitSCscapewasusedvisuaieferropsisrelaedgenesandomenon codingRNAsinteractionnetwork.CIBROSORTwasusedevaluateabundance immunocytes，revealingtheefect immune responseinAus：itrosisedifrellpredsDseauchriigt）， glutamatereceprsubunit 3（GRIA3），Promin-2（PROM2），interleukin-1β（IL1β）andsoon.Geneonlog（GO）analysisandGeneSet EnrichmentAnalysis（GSEA）foundpathwayssuchasgulatiohelialcellprliferationmembraneraftndvasuladothelia growthfacr（VEGF）pathwayenrichedinthisdiseases.Regularynetworkandimmunocyteinfitrationabundanceanalysiswere performedevaluatetheunderlyingmechanisminAS.Conclusion：ThityDEGsassociatedwithferopsiswerefoundinASand corelatedwitpathologicalprogresiontedisease.Tepathogenesisandpotentialmoleculartargetsthediseasewerediscused forpotentialtreatmenttargetsinthefuture.Howeverteunderlyingpathogenesisandpotentialmoleculartargetsstiledore comprehensive and in-depth studies.

sywordsatherosclerosis; ferropsis; Hub gene; gene co-expression; bioinformatics analy

動(dòng)脈粥樣硬化（atherosclerosis，AS）是一種主要影響大中型動(dòng)脈的慢性炎癥性疾病[13]，是由氧化型低密度脂蛋白（oxidized lowdensity lipoprotein，ox-LDL）膽固醇在動(dòng)脈壁中積聚，從而引發(fā)一系列連鎖炎癥反應(yīng)。（剩余18310字）