,95%CI(-1.16,-0.81), P<0.00001 ]、白介素-6(IL-6)[ MD=-3.33 95% CI(—3.62,-3.05), P<0.000 01 明顯降低,左室射血分?jǐn)?shù)(LVEF)明顯增加 MD=4.71 , 95% CI(4.13,5.28), P<0.000 01 ]。結(jié)論:現(xiàn)有研究表明,沙庫巴曲纈沙坦預(yù)防心房顫動射頻消融術(shù)后晚期復(fù)發(fā)療效確切。受納入文獻(xiàn)數(shù)量和質(zhì)量限制,尚需要更多高質(zhì)量研究予以驗(yàn)證。-龍?jiān)雌诳W(wǎng)" />

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沙庫巴曲纈沙坦預(yù)防心房顫動射頻消融術(shù)后晚期復(fù)發(fā)的系統(tǒng)評價(jià)

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AbstractObeieluaetienofiateurreofrialilfadiofrei Methods:ThedatabasesofPubMed,theCochraneLibrary,WebofScience,CNKl,WanFangData,andVIPDataweresearchedto colectanddooldralss)evaatingacbriaanitreamntoftriafibilioadiofrebatio TheretrievaltimewasfromtheestablishmentofthedatabasetoMay1024.Tworesearchersindependentlyscrenedteiterature, extractedthedataevaluatedtheriskofasinteincudedsudiesndperformedaMetaanalysisusingRevan5.3softwaresults: Atotalof10RCsinvolving929patientsereincudedTeresultsofMetaanalysisshowedthatcomparedwiththecontrolgroupthelate recurrencerate( OR=0.39 95%C1 0.30-0.51, P<0.000 01 ),leftatrialdiameter(LAD) MD=-0.25 95%C 1—0.32-—0.18, P<0.000 01 ),left atrial volume index(LAVI) (N 1D=-5.06 ,95%Cl—7.13--2.99, 1),leftventricularend-diastolicdiameter(LVEDD) MD=-0.16 95%Cl—0.25--0.07, P<0.000 01 ),N-terminal pro-brain natriuretic peptide(NT-proBNP)(MD —133.87, 95% Cl—157.61-—110.13, P<0.000 01),C-reactive protein(CRP) ND=-0.98 = 95%01-1.16-0.81 , P<0.000 01),interleukin-6(IL-6) (MD=-3.33 5 95%Cl—3.62--3.05, P<0.000 01 )decreased significantly in the experimental group,and left ventricular ejection fraction(LVEF)( MD= 4.71,95%Cl4.13-5.28, P<0.000 01)increased significantly.Conclusion:Current research indicates that sacubitri/valsartan is efective in preventinglatcudiofrblairlfiaiouetoliidantitdaiofddiu theabove conclusions need to be verified by more high-quality studies.

Keywordsatrialfibrilation;sacubitril/valsartan;radiofrequencyablation;late recurrence;systematicreview

心房顫動(atrialfibrillation,AF)是臨床常見的心律失常類型。(剩余11049字)

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