基于生物信息學分析膿毒癥心肌病差異基因及潛在治療中藥預(yù)測

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AbstractObjective：Toexplrediferentialgenesinsepticcardomyopathyandpreictionpotetiltherapeutictraditioal medicinesbasedonbioinformatics.Methods：GSE79962chipdatawasdownloadedfromthegeneexpresiondatabase.elevant diferentialyexpressedgeneswerescreenedusingRlanguage，andthediferentiallyexpressedgeneswereanalyzedinthegene ontologyandKyotoEncyclopedia GenesandGenomesdatabases.proteininteractionnetworkwasconstructedthroughthe STRINGwebsite.coregenesthediferentiallexpressedgeneswereanalyzedusingCytoscapestwareanditspluginCytoHuba. coregenesweremutuallymappedwiththemedicalontologinformationretrievalplatform （CoremineMedical）toscreentherelevant traditionalCineedicfrtetreatmentesusAtotal7diftillexpresedgeseresreedoutiding 77up-regulatedgenesand160down-regulated genes.pathwayenrichmentmainlyincludedthetransforminggrowth factorTGF） -β signalingpathwaytheadvancedadvancedglycationendproductAGE）advancedgycationendproductreceptor（RAGE）signling pathwayindiabeticcomplications，etc.Tekeycoregenesscreenedmainlyincludesignaltransducerandactivatortranscrition3 （STAT3），MYC，signaltransductiomolecule3（D3），UNB，serpincadeEmember1（SERPINE1），osphoiostideiae regulatorysubuni）andCAancerndingproteideltaCEBD）elevantrapeuticaditioalCnedii mainlyincludedisengierinsnpaeoelctfloratulptmeric，ubarbpanaxgsngtc.Concusionaalyisf diferentialy expressdgenesandkeycoregenesintissudycouldpromoteteunderstandingthepathogenesisSCMandprovide potentialgenetargetsandresearchanddevelopmentideasforthedevelopmentnewdrugsintraditionalmedicineforthe treatment SCM.

Keywordsseptic cardiomyopathy; bioinformatics; differentially expressed genes; medicine

膿毒癥心肌?。╯epsticcardiomyopathy，SCM）是膿毒癥中常見的并發(fā)癥之一，往往預(yù)示不良預(yù)后，顯著提高病人的死亡率1。（剩余7833字）