胎盤代謝組學(xué)方法在異常妊娠研究中的應(yīng)用

［摘要］ 異常妊娠與胎盤功能失調(diào)密切相關(guān)，通過胎盤代謝組學(xué)分析，可以了解異常妊娠的特有代謝紊亂和病理機制。本文對胎盤代謝組學(xué)在各類異常妊娠中的應(yīng)用成果進行綜述，并對其現(xiàn)狀及前景進行討論。

［關(guān)鍵詞］ 胎盤；代謝組學(xué)；妊娠并發(fā)癥；新生兒；綜述

［中圖分類號］ R714.56;R722.1

［文獻標志碼］ A

［文章編號］ 2096-5532（2024）06-0941-04

doi：10.11712/jms.2096-5532.2024.60.195

［開放科學(xué)（資源服務(wù)）標識碼（OSID）］

［網(wǎng)絡(luò)出版］ https：//link.cnki.net/urlid/37.1517.R.20250107.1910.005;2025-01-08 13：52：56

The application of placental metabolomics in abnormal pregnancies

ZHANG Fanzhen， LIU Qiang， ZHANG Haixia

（School of Clinical Medicine， Weifang Medical University， Weifang 26105  China）

［Abstract］ Abnormal pregnancies are closely associated with placental dysfunction， and placental metabolomics can help to understand the unique metabolic disruptions and pathological mechanisms in abnormal pregnancies. This article reviews the application of placental metabolomics in various types of abnormal pregnancies and discusses its current status and future prospects.

［Key words］ placenta; metabolomics; pregnancy complications; infant， newborn; review

受到基因和環(huán)境的共同影響，我國異常妊娠的發(fā)生率超過5%[1]。（剩余12730字）