鐵死亡在乳腺癌治療中的研究進(jìn)展

［摘要］ 鐵死亡是一種不同于凋亡、壞死的細(xì)胞程序性死亡，與許多生物過程有關(guān)。一些研究發(fā)現(xiàn)，鐵死亡能協(xié)同化療、放療、免疫治療等，增強(qiáng)對(duì)乳腺癌的療效，誘導(dǎo)鐵死亡可能成為腫瘤治療的新靶點(diǎn)。本文對(duì)鐵死亡的發(fā)生途徑及其在乳腺癌治療中的研究進(jìn)行了綜述。

［關(guān)鍵詞］ 鐵死亡；乳腺腫瘤；脂質(zhì)過氧化作用；綜述

［中圖分類號(hào)］ R737.9

［文獻(xiàn)標(biāo)志碼］ A

［文章編號(hào)］ 2096-5532（2024）06-0937-04

doi：10.11712/jms.2096-5532.2024.60.204

［開放科學(xué)（資源服務(wù)）標(biāo)識(shí)碼（OSID）］

［網(wǎng)絡(luò)出版］ https：//link.cnki.net/urlid/37.1517.R.20250113.1932.002;2025-01-14 12：03：25

Research advances in ferroptosis in the treatment of breast cancer

LIU Zeyu， LIU Jiannan， SUN Ping

（Department of Oncology， The Affiliated Yantai Yuhuangding Hospital of Qingdao University， Yantai 264000， China）

［Abstract］ Ferroptosis is a type of programmed cell death different from apoptosis and necrosis and is associated with many biological processes. Several studies have shownthat ferroptosis can synergize with chemotherapy， radiotherapy， and immunotherapy to enhance the efficacy of treatment for breast cancer， and induction of ferroptosis may become a new target in tumor therapy. This article reviewsthe pathways of ferroptosis and related studies in the treatment of breast cancer.

［Key words］ ferroptosis; breast neoplasms; lipid peroxidation; review

鐵參與細(xì)胞生長(zhǎng)和增殖的許多過程，鐵死亡是一種以鐵依賴性的脂質(zhì)過氧化為主要特征的細(xì)胞程序性死亡。（剩余13018字）